The Cydem VT Automated Clone Screening System, a high-throughput microbioreactor platform for automated top clone screening, is introduced by Beckman Coulter Life Sciences, a division of Danaher Corporation. By reducing manual laboratory processes in Cell Line Development by 90% in a single experiment and doing away with numerous following standard screening stages, the revolutionary Cydem VT System shortens time to market for biologic drug development and monoclonal antibody-based medicines.
The Cydem VT System gives labs superior cultivating conditions that are closer to biomanufacturing production and more dependable clones than previous approaches by providing early responses for cell growth and productivity in the cell line development process. The Chinese Hamster Ovary (CHO) cell line development process for monoclonal antibody (mAb) production is best served by the all-in-one high-throughput screening platform.
Product manager Dr. Sebastian Hofzumahaus stated, “Our Cydem VT Automated Clone Screening System offers an exciting revolution to expedite critical research therapies for illnesses, including autoimmune diseases and many types of cancer.” “We listened to the worries about choosing clones with low productivity and saw the urgent need to create a user-friendly system that reliably and consistently finds the best clones.We can guarantee more accuracy with fewer steps by offering early responses and improved cultivation conditions, which lowers the possibility of poor clones and helps labs find their next big discovery even more quickly while also improving human health.
The system gives lab managers a more efficient, higher-throughput way to screen for top clones by combining several reliable Beckman Coulter Life Sciences technologies, such as liquid handling, antibody titer, microbioreactor, and cell health (cell count & viability) measurements, into a single, cutting-edge platform. It enables up to 96 bioreactors with individual gassing to be monitored and grown in fed batches under parallel pH control.
During an experiment, automated processes provide for at least three days of walk-away time. Continuous control over crucial growth parameters is made possible by online, non-invasive measurements of biomass, dissolved oxygen (DO), and pH. The best clones are chosen with knowledge thanks to on-deck measurements of cell concentration, vitality, and titer concentration.
